Dose-Response Relationships in Prenatal Toxicity
نویسندگان
چکیده
منابع مشابه
Modeling of dose-response relationships.
The main dose-response models for chronic toxicity are considered. For dichotomous response, the log probit, multi-hit, and multistage models are presented. For time-to-occurrence response, the log-normal and three variations of multistage models are presented. Finally, the Cornfield hockey-stick model is considered, and, for low-dose extrapolation, it is suggested that response be taken to be ...
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Taking as a starting point a set of simple quantitative hypotheses regarding the possible relationships between cell receptors and effector molecules, a statistical algorithm or generative model is developed that simulates different types of dose-response profiles and whose results are used in two ways, both subject to empirical verification. In the first of these, the suitability of several co...
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ژورنال
عنوان ژورنال: Congenital Anomalies
سال: 1987
ISSN: 0914-3505,1741-4520
DOI: 10.1111/j.1741-4520.1987.tb00711.x